All compounds

40 compounds mapped

Polyphenols, polyamines, peptides, NAD+ precursors, and therapeutic compounds — each linked to foods, precursor chains, and the research behind them.

antioxidantNAD+AMPKmethylationmitochondrialmTORmitophagysenolyticNrf2autophagysirtuintissue-repairtelomere

Food-sourced compounds

Compounds found in food at meaningful concentrations. Traceable to growers.

Limited evidence entries

These entries have surfaced through the pipeline but lack corroboration. Check individual pages for current evidence state.

Anthocyanins

antioxidant+ supplement

Red-blue-purple flavonoid pigments in blueberries, blackberries, black raspberries, elderberries, and red cabbage. Studied in endothelial function and cognitive aging; rapidly metabolized so whole-food intake is preferred over extracts.

4 food sourcesLimited evidence

Apigenin

NAD++ supplement

Discover 0 whole food sources of Apigenin, certified organic growers, and the latest longevity research on this bioactive compound.

3 food sourcesLimited evidence

Astaxanthin

antioxidant+ supplement

Red xanthophyll carotenoid produced by the microalga Haematococcus pluvialis and concentrated in salmon, krill, and shrimp that feed on it. Lipid-soluble antioxidant studied for mitochondrial function, skin UV protection, and exercise endurance.

1 food sourceLimited evidence

Berberine

AMPK+ supplement

Discover 0 whole food sources of Berberine, certified organic growers, and the latest longevity research on this bioactive compound.

0 food sourcesLimited evidence

Choline

methylation+ supplement

Essential nutrient from eggs, liver, soybeans, and fish. Precursor to acetylcholine and the methyl donor betaine; critical for methylation, membrane phospholipids, and liver lipid export. Most adults fall short of the adequate intake.

1 food sourceLimited evidence

Coenzyme Q10 (Ubiquinol)

mitochondrial+ supplement

Lipid-soluble electron carrier in the mitochondrial electron transport chain, present in organ meats, sardines, mackerel, and in lower amounts across most tissues. Endogenous synthesis declines with age. Ubiquinol (reduced form) is the active antioxidant species.

2 food sourcesLimited evidence

Curcumin

mTOR+ supplement

Active compound in turmeric root. Anti-inflammatory, antioxidant.

1 food sourceLimited evidence

EGCG

antioxidant+ supplement

Epigallocatechin gallate. Catechin from green tea. Antioxidant, metabolic benefits.

2 food sourcesLimited evidence

Ellagitannins

mitophagy+ supplement

Discover 3 whole food sources of Ellagitannins, certified organic growers, and the latest longevity research on this bioactive compound.

4 food sourcesLimited evidence

Ergothioneine

mitochondrial+ supplement

Discover 1 whole food sources of Ergothioneine, certified organic growers, and the latest longevity research on this bioactive compound.

1 food sourceLimited evidence

Fisetin

senolytic+ supplement

Polyphenol found in strawberries, apples. Senolytic. Removes senescent cells.

2 food sourcesLimited evidence

Glucoraphanin

Nrf2+ supplement

Discover 1 whole food sources of Glucoraphanin, certified organic growers, and the latest longevity research on this bioactive compound.

1 food sourceLimited evidence

Hesperidin

antioxidant+ supplement

Flavanone glycoside abundant in the peel and pulp of oranges, lemons, and other citrus. Studied for microvascular function, endothelial health, and metabolic parameters. Metabolized to hesperetin, which reaches circulation.

1 food sourceLimited evidence

Hydroxytyrosol

AMPK+ supplement

Discover 1 whole food sources of Hydroxytyrosol, certified organic growers, and the latest longevity research on this bioactive compound.

1 food sourceLimited evidence

Kaempferol

AMPK+ supplement

Discover 1 whole food sources of Kaempferol, certified organic growers, and the latest longevity research on this bioactive compound.

2 food sourcesLimited evidence

Luteolin

senolytic+ supplement

Flavone found in celery, parsley, chamomile, and artichoke. Studied for senolytic activity (clearance of senescent cells) and neuroinflammation modulation. Often discussed alongside fisetin and quercetin in the senolytic literature.

3 food sourcesLimited evidence

Lycopene

antioxidant+ supplement

Red tetraterpene carotenoid concentrated in cooked tomatoes, watermelon, and pink grapefruit. Studied in cardiovascular health and prostate cancer epidemiology. Bioavailability improves with fat and heat processing.

1 food sourceLimited evidence

Melatonin

antioxidant+ supplement

Indoleamine synthesized from tryptophan in the pineal gland and present in foods including pistachios, tart cherries, and eggs. Circadian regulator and potent mitochondrial antioxidant. Food-sourced doses are orders of magnitude lower than supplement doses.

2 food sourcesLimited evidence

Metformin

Metformin: longevity research, bioavailability, and emerging evidence from peer-reviewed studies.

0 food sourcesLimited evidence

Niacin (Vitamin B3)

NAD++ supplement

Discover 0 whole food sources of Niacin (Vitamin B3), certified organic growers, and the latest longevity research on this bioactive compound.

0 food sourcesLimited evidence

NMN

NAD++ supplement

Nicotinamide mononucleotide. NAD+ precursor studied for mitochondrial function.

2 food sourcesLimited evidence

NR (Nicotinamide Riboside)

NAD++ supplement

Discover 0 whole food sources of NR (Nicotinamide Riboside), certified organic growers, and the latest longevity research on this bioactive compound.

0 food sourcesLimited evidence

Oleocanthal

autophagy

Pungent phenolic compound in high-quality extra-virgin olive oil responsible for the throat-burn sensation. Inhibits COX-1/COX-2 in a manner mechanistically similar to ibuprofen. Studied for anti-inflammatory and autophagy-related effects.

1 food sourceLimited evidence

Oleuropein

AMPK+ supplement

Bitter secoiridoid polyphenol from olive leaves and unripe olives (highest in early-harvest extra-virgin olive oil). Studied for AMPK activation, blood pressure, and lipid oxidation. Hydrolyzes to hydroxytyrosol in vivo.

1 food sourceLimited evidence

Pterostilbene

sirtuin+ supplement

Discover 1 whole food sources of Pterostilbene, certified organic growers, and the latest longevity research on this bioactive compound.

1 food sourceLimited evidence

Pyrroloquinoline Quinone (PQQ)

mitochondrial+ supplement

Redox cofactor found in natto, parsley, green tea, and human breast milk. Studied for stimulation of mitochondrial biogenesis via PGC-1α signaling. Typical dietary intake is well below research doses used in trials.

3 food sourcesLimited evidence

Quercetin

senolytic+ supplement

Flavonoid found in apples, onions, berries. Senolytic properties.

5 food sourcesLimited evidence

Resveratrol

sirtuin+ supplement

Polyphenol found in red grapes, wine, and berries. Studied for sirtuin activation and longevity.

4 food sourcesLimited evidence

Spermidine

autophagy+ supplement

Polyamine compound. Induces autophagy. Found in aged cheese, mushrooms, wheat germ.

4 food sourcesLimited evidence

Sulforaphane

Nrf2+ supplement

Isothiocyanate from cruciferous vegetables. Activates Nrf2 pathway.

3 food sourcesLimited evidence

Taurine

mitochondrial+ supplement

Sulfur-containing amino acid concentrated in seafood and meats; synthesized endogenously. A 2023 Science paper (Singh et al., Columbia) reported taurine deficiency as a driver of aging and supplementation extending lifespan in mice, non-human primates, and middle-aged worms.

2 food sourcesLimited evidence

Theaflavins

antioxidant

Reddish polyphenols formed during black tea oxidation from catechin precursors (including EGCG). Studied for cardiovascular markers and lipid metabolism. Unique to fermented/oxidized teas — not present in green tea.

1 food sourceLimited evidence

TMG (Trimethylglycine)

methylation+ supplement

Discover 2 whole food sources of TMG (Trimethylglycine), certified organic growers, and the latest longevity research on this bioactive compound.

3 food sourcesLimited evidence

Urolithin A

mitophagy+ supplement

Discover 2 whole food sources of Urolithin A, certified organic growers, and the latest longevity research on this bioactive compound.

2 food sourcesLimited evidence

Ursolic Acid

mTOR+ supplement

Pentacyclic triterpenoid in apple peels, basil, rosemary, and holy basil (tulsi). Studied for muscle maintenance and metabolic effects; animal work shows attenuation of muscle atrophy and improvements in glucose handling.

2 food sourcesLimited evidence

Therapeutic peptides

Synthetic peptides with no dietary source. Discussed in longevity research and researcher stacks. No food traceability — research context only.

⚠ These are investigational compounds. Information is educational only. Not medical advice.

Limited evidence entries

These entries have surfaced through the pipeline but lack corroboration. Check individual pages for current evidence state.

AOD-9604

mitochondrial

Fragment of human growth hormone. Studied for fat loss and metabolic health.

No food source — research context onlyLimited evidence

BPC-157

tissue-repair

Body Protection Compound. Peptide studied for tissue repair and neuroprotection.

No food source — research context onlyLimited evidence

GLP-1 Agonist

mTOR

Glucagon-like peptide-1 agonist. Studied for metabolic and longevity benefits.

No food source — research context onlyLimited evidence

Senolytics (FOXO4-DRI)

senolytic

Senolytic compound that removes senescent cells. Investigational.

No food source — research context onlyLimited evidence

TA-65

telomere

Telomerase activator. Studied in longevity research for telomere lengthening.

No food source — research context onlyLimited evidence