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Spermidine

Compoundautophagy

Polyamine compound. Induces autophagy. Found in aged cheese, mushrooms, wheat germ.

Food sources

NattoPrimary
16–25 mg/100g
Glycine max (fermented)
→
Wheat GermPrimary
2–3 mg/100g
Triticum aestivum (germ)
→
Shiitake MushroomPrimary
0.08–0.1 mg/100g
Lentinula edodes
→
Aged Cheddar Cheese
→

Research citations

Cardioprotection and lifespan extension by the natural polyamine spermidine
Eisenberg T et al. · Nature Medicine · 2016
peer-reviewedDOI →
Spermidine in health and disease
Madeo F et al. · Science · 2018
peer-reviewedDOI →

Citations link to peer-reviewed publications. Virisource is not affiliated with any author or institution. Not medical advice.

Recent research mentioning Spermidine

  1. [USDA Polyamine Database Development Study] spermidine in green peas — concentration update
    USDA Polyamine Database Development Study · USDA Polyamine Database Development Study · 2026-10-01ai deep research
  2. [Spermidine Research Review] spermidine in shiitake mushrooms — concentration update
    Spermidine Research Review · Spermidine Research Review · 2026-10-01ai deep research
  3. [Spermidine Food Database Research] spermidine in chickpeas — new food source
    Spermidine Food Database Research · Spermidine Food Database Research · 2026-10-01ai deep research
  4. [PMC - Polyamines in Foods Database] spermidine in chickpeas — concentration update
    PMC - Polyamines in Foods Database · PMC - Polyamines in Foods Database · 2026-07-01ai deep research
  5. [PMC - Polyamines in Foods Database] spermidine in corn — new food source
    PMC - Polyamines in Foods Database · PMC - Polyamines in Foods Database · 2026-07-01ai deep research
  6. [PMC - Polyamines in Foods Database] spermidine in green peas — concentration update
    PMC - Polyamines in Foods Database · PMC - Polyamines in Foods Database · 2026-07-01ai deep research
  7. [Efficient biosynthesis of spermidine via whole-cell catalysis with a multi-enzyme cascade system].
    Song Y, Yang F, Wang S, Rao Z, Xu M · Sheng Wu Gong Cheng Xue Bao · 2026-03-02pubmed
  8. Spermidine Supplementation Reduces Genetic Damage in the Liver and Bone Marrow of Rodents.
    Barcelos Chacon J, Duarte MC, Carvalho MO, Ávila PF, Menon IC · ACS Omega · 2026-03-02pubmed

Continuously updated by the research discovery pipeline. New citations appear automatically within a day of publication.

How it works

Spermidine is a polyamine compound originally isolated from semen and also found in ribosomes and living tissues and has various metabolic functions in organisms.

Source: Wikipedia

Chemistry

IUPAC name
N'-(3-aminopropyl)butane-1,4-diamine
Formula
C7H19N3
PubChem
CID 1102 →

Source: PubChem (NIH, public domain)

Learn more

Wikipedia →PubChem CID 1102 →

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