The foundation

Food-first longevity.
Science-led.

Virisource maps the relationship between food and longevity compounds — including the upstream foods your body converts into those compounds. The science behind this is broad, evolving, and grounded in peer-reviewed research.

We don't lock to any single theory. As research evolves — as Sinclair revises his protocols, as new mechanisms are confirmed, as new foods are studied — the directory evolves with it.

How we think

Five principles that guide
what we include

01

Food before supplements

Where a whole food contains a longevity compound — or a precursor the body converts into one — that food is the primary entry. Supplements are downstream. We map upstream.

02

Stress produces potency

Plants under environmental stress — drought, UV, poor soil — produce higher concentrations of protective polyphenols. Growing method matters as much as species. We track both.

03

Precursor chains, not just direct sources

Some of the most effective compounds never appear directly in food. They are produced when the body converts something else. We map those conversion chains explicitly.

04

Evidence-tiered, not opinion-based

Every compound and food relationship carries a confidence tier: peer-reviewed study, credible researcher consensus, or community-reported. You can filter by what matters to you.

05

Living, not static

Longevity science changes. Researcher positions evolve. New studies revise old assumptions. Virisource is updated continuously — not published once and left to go stale.

One key mechanism

Xenohormesis — why stressed
plants are different

When a plant is stressed — by drought, UV radiation, poor soil, or predators — it produces polyphenols and other protective compounds to survive. These molecules are the plant's stress response made chemical.

When we consume them, our cells detect these molecules as mild stressors and activate the same ancient survival pathways — sirtuins switch on, cellular cleanup begins, inflammation decreases.

This is xenohormesis — and it explains why a dry-farmed blueberry grown under stress contains significantly more pterostilbene than one grown in ideal conditions. The stress is the point.

Xenohormesis is one of several mechanisms Virisource tracks. It's not the whole story — but it's why growing method appears on every food entry in the directory.

Pathways

Key pathway themes

Editorially-curated groupings of the core longevity pathways Virisource tracks. The database currently has 13 pathways tracked — see the full list below these themes. Status reflects current scientific consensus.

NAD⁺ / Sirtuin pathway

Core

NAD⁺ fuels sirtuins — proteins that regulate DNA repair, inflammation, and cellular aging. Levels decline with age. Foods rich in NMN, NR, and niacin precursors help restore them.

Sinclair et al., Cell 2013; multiple replications

Compounds

NMNNRNiacin (B3)Tryptophan

Food sources

EdamameBroccoliAvocadoMushroomsTurkey

AMPK activation

Core

AMPK is the body's energy sensor. When activated — by caloric restriction, exercise, or certain plant compounds — it triggers cellular cleanup, fat burning, and mitochondrial biogenesis.

Multiple peer-reviewed studies; Attia synthesis

Compounds

BerberineQuercetinResveratrolEGCG

Food sources

BarberriesCapersGrapesGreen teaOnions

Mitophagy / Urolithin A

Core

Mitophagy clears damaged mitochondria. Urolithin A — produced when your gut microbiome converts ellagitannins from pomegranates and walnuts — directly activates this cleanup process.

Ryu et al., Nature Medicine 2016; Amazentis trials

Compounds

Urolithin AEllagitanninsPunicalagin

Food sources

PomegranateWalnutsRaspberriesStrawberries

Polyamine / Spermidine

Core

Spermidine triggers autophagy — the cellular recycling process. Levels decline with age. Found at high concentrations in fermented foods, wheat germ, and certain mushrooms.

Madeo et al., Science 2018

Compounds

SpermidineSperminePutrescine

Food sources

NattoWheat germShiitakeAged cheeseMango

Nrf2 / Sulforaphane

Core

Sulforaphane activates Nrf2, the master regulator of antioxidant response. Broccoli sprouts contain glucoraphanin — a precursor your gut converts via myrosinase into sulforaphane.

Fahey & Talalay; Patrick synthesis on FoundMyFitness

Compounds

SulforaphaneGlucoraphaninIndole-3-carbinol

Food sources

Broccoli sproutsKaleCabbageBrussels sprouts

mTOR inhibition

Emerging

mTOR drives cellular growth but when chronically activated accelerates aging. Caloric restriction, fasting, and certain plant compounds suppress mTOR, extending lifespan in multiple models.

Harrison et al., Nature 2009; Longo fasting research

Compounds

Rapamycin analogsFisetinCurcumin

Food sources

StrawberriesApplesPersimmonsTurmeric

Epigenetic reprogramming

Frontier

Sinclair's information theory of aging proposes that epigenetic noise — not DNA damage — is the primary driver of aging. Certain interventions may partially reset this. Food correlates are still being mapped.

Sinclair, Lifespan 2019; ongoing lab work

Compounds

TMGMethyl donorsNMN

Food sources

BeetsSpinachQuinoaEggs
CoreMultiple replicated studies
EmergingStrong early evidence
FrontierPromising, less replicated

All tracked pathways (13)

Each distinct pathway value currently tagged on compounds in the directory. New pathways appear here automatically as the catalog grows. Click through to see compounds mapped to each.

antioxidant7 compoundsmitochondrial5 compoundsNAD+4 compoundsAMPK4 compoundssenolytic4 compoundsmTOR3 compoundsautophagy2 compoundsmethylation2 compoundsmitophagy2 compoundssirtuin2 compoundsNrf22 compoundstelomere1 compoundtissue-repair1 compound

Staying current

A living directory,
not a static list

Sinclair has revised his supplement stack publicly multiple times. Attia walked back certain supplement recommendations after new data emerged. Longo's fasting research continues to refine which foods matter most. We track all of it — and update the directory when the science moves.

Publication monitoring

Weekly

An AI-assisted scan of PubMed, bioRxiv, and Google Scholar surfaces new papers matching longevity compound terms. Sinclair's lab page, podcast, and public statements are tracked directly. When a researcher revises a position — or new evidence contradicts an existing entry — the directory is updated.

Sources

PubMedbioRxivHarvard Sinclair LabLifespan PodcastFoundMyFitnessGoogle Scholar

Grower discovery

Monthly

An AI crawler searches USDA farmer registries, Local Harvest, CSA directories, and targeted web searches for farms using stress-inducing or high-compound growing methods. All candidates land in the review queue — nothing goes live without human approval.

Sources

USDA Farmers Market DirectoryLocal HarvestCSA databasesTargeted web search

Compound data refresh

Quarterly

Concentration data from FooDB, Phenol-Explorer, and USDA FoodData Central is diffed against the database. Significant changes are flagged and evidence tiers are updated. New compounds identified in research are added to the taxonomy.

Sources

FooDBPhenol-ExplorerUSDA FoodData CentralNew journal entries

Primary sources

Researchers we track

Virisource tracks researchers with demonstrated contributions to longevity science. When their published positions evolve, we update the directory. This list grows as the catalog grows.

David Sinclair
Professor of Genetics
Harvard Medical School
NAD+sirtuinslongevity
Nathan Bryan
Nitric Oxide Researcher
UT Health Houston
nitric oxidecardiovascularblood pressure
Peter Attia
Physician & Longevity Researcher
Early Medical
metabolic healthexercisenutrition
Rhonda Patrick
Biomedical Scientist
FoundMyFitness
saunaheat stresscold exposure
Valter Longo
Professor of Gerontology
USC Leonard Davis School
fastingcaloric restrictioncellular regeneration
Amy Chan
Andrew Huberman
Professor of Neurobiology
Stanford University
neurosciencesleepdopamine
Cathy Lanier
Chris Paul
Daniel Sodickson
George Mack
Jessie Inchauspé
Max Jolliffe
Max Lugavere
Natalie Crawford
Oz Pearlman
Tristan Harris
Will Guidara

Virisource is not affiliated with any of these researchers. We track their published work and public statements as primary sources. Nothing on this site constitutes medical advice.