How we think
Five principles that guide
what we include
Food before supplements
Where a whole food contains a longevity compound — or a precursor the body converts into one — that food is the primary entry. Supplements are downstream. We map upstream.
Stress produces potency
Plants under environmental stress — drought, UV, poor soil — produce higher concentrations of protective polyphenols. Growing method matters as much as species. We track both.
Precursor chains, not just direct sources
Some of the most effective compounds never appear directly in food. They are produced when the body converts something else. We map those conversion chains explicitly.
Evidence-tiered, not opinion-based
Every compound and food relationship carries a confidence tier: peer-reviewed study, credible researcher consensus, or community-reported. You can filter by what matters to you.
Living, not static
Longevity science changes. Researcher positions evolve. New studies revise old assumptions. Virisource is updated continuously — not published once and left to go stale.
One key mechanism
Xenohormesis — why stressed
plants are different
When a plant is stressed — by drought, UV radiation, poor soil, or predators — it produces polyphenols and other protective compounds to survive. These molecules are the plant's stress response made chemical.
When we consume them, our cells detect these molecules as mild stressors and activate the same ancient survival pathways — sirtuins switch on, cellular cleanup begins, inflammation decreases.
This is xenohormesis — and it explains why a dry-farmed blueberry grown under stress contains significantly more pterostilbene than one grown in ideal conditions. The stress is the point.
Xenohormesis is one of several mechanisms Virisource tracks. It's not the whole story — but it's why growing method appears on every food entry in the directory.
Pathways
Key pathway themes
Editorially-curated groupings of the core longevity pathways Virisource tracks. The database currently has 13 pathways tracked — see the full list below these themes. Status reflects current scientific consensus.
NAD⁺ / Sirtuin pathway
CoreNAD⁺ fuels sirtuins — proteins that regulate DNA repair, inflammation, and cellular aging. Levels decline with age. Foods rich in NMN, NR, and niacin precursors help restore them.
Sinclair et al., Cell 2013; multiple replications
Compounds
Food sources
AMPK activation
CoreAMPK is the body's energy sensor. When activated — by caloric restriction, exercise, or certain plant compounds — it triggers cellular cleanup, fat burning, and mitochondrial biogenesis.
Multiple peer-reviewed studies; Attia synthesis
Compounds
Food sources
Mitophagy / Urolithin A
CoreMitophagy clears damaged mitochondria. Urolithin A — produced when your gut microbiome converts ellagitannins from pomegranates and walnuts — directly activates this cleanup process.
Ryu et al., Nature Medicine 2016; Amazentis trials
Compounds
Food sources
Polyamine / Spermidine
CoreSpermidine triggers autophagy — the cellular recycling process. Levels decline with age. Found at high concentrations in fermented foods, wheat germ, and certain mushrooms.
Madeo et al., Science 2018
Compounds
Food sources
Nrf2 / Sulforaphane
CoreSulforaphane activates Nrf2, the master regulator of antioxidant response. Broccoli sprouts contain glucoraphanin — a precursor your gut converts via myrosinase into sulforaphane.
Fahey & Talalay; Patrick synthesis on FoundMyFitness
Compounds
Food sources
mTOR inhibition
EmergingmTOR drives cellular growth but when chronically activated accelerates aging. Caloric restriction, fasting, and certain plant compounds suppress mTOR, extending lifespan in multiple models.
Harrison et al., Nature 2009; Longo fasting research
Compounds
Food sources
Epigenetic reprogramming
FrontierSinclair's information theory of aging proposes that epigenetic noise — not DNA damage — is the primary driver of aging. Certain interventions may partially reset this. Food correlates are still being mapped.
Sinclair, Lifespan 2019; ongoing lab work
Compounds
Food sources
All tracked pathways (13)
Each distinct pathway value currently tagged on compounds in the directory. New pathways appear here automatically as the catalog grows. Click through to see compounds mapped to each.
Primary sources
Researchers we track
Virisource tracks researchers with demonstrated contributions to longevity science. When their published positions evolve, we update the directory. This list grows as the catalog grows.
Virisource is not affiliated with any of these researchers. We track their published work and public statements as primary sources. Nothing on this site constitutes medical advice.