Longevity pathway
Mitochondrial function
Mitochondria generate cellular energy via oxidative phosphorylation. Mitochondrial dysfunction is a hallmark of aging; compounds supporting biogenesis, membrane integrity, or ETC efficiency target this pathway.
Source: Wikipedia
5 compounds on this pathway
Each compound is linked to its known food sources. Click through for citations and precursor chains.
Coenzyme Q10 (Ubiquinol)
Lipid-soluble electron carrier in the mitochondrial electron transport chain, present in organ meats, sardines, mackerel, and in lower amounts across most tissues. Endogenous synthesis declines with age. Ubiquinol (reduced form) is the active antioxidant species.
Ergothioneine
Discover 1 whole food sources of Ergothioneine, certified organic growers, and the latest longevity research on this bioactive compound.
Pyrroloquinoline Quinone (PQQ)
Redox cofactor found in natto, parsley, green tea, and human breast milk. Studied for stimulation of mitochondrial biogenesis via PGC-1α signaling. Typical dietary intake is well below research doses used in trials.
Taurine
Sulfur-containing amino acid concentrated in seafood and meats; synthesized endogenously. A 2023 Science paper (Singh et al., Columbia) reported taurine deficiency as a driver of aging and supplementation extending lifespan in mice, non-human primates, and middle-aged worms.
AOD-9604
Fragment of human growth hormone. Studied for fat loss and metabolic health.